RNA-Sequencing 2011

Transcriptomics underpins many fields of biological science. While RNA-Seq is perhaps the most complex NGS application, the determination of expression levels of specific genes, differential splicing, and allele-specific expression of transcripts addresses many biological-related issues. These range from basic cellular function to the understanding of biological events that govern the development and progression of disease. NGS is transforming our understanding of transcriptomes and giving new biological insights into the “active genome.”